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ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanism

In budding yeast, TEL1 encodes a protein closely related to ATM. Xrs2 is an Nbs1 homolog and forms a complex with Mre11 and Rad50. We show here that Tel1 associ ates with double-strand breaks (DSBs) through a mechanism dependent on the C terminus of Xrs2. Although Xrs2 is required for the DNA degrad...

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Bibliografiske detaljer
Main Authors: Nakada, Daisuke, Matsumoto, Kunihiro, Sugimoto, Katsunori
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC196250/
https://ncbi.nlm.nih.gov/pubmed/12923051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1099003
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