Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains

On the histone H3 tail, Lys 9 and Lys 27 are both methylation sites associated with epigenetic repression, and reside within a highly related sequence motif ARKS. Here we show that the chromodomain proteins Polycomb (Pc) and HP1 (heterochromatin protein 1) are highly discriminatory for binding to th...

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Bibliografische gegevens
Hoofdauteurs: Fischle, Wolfgang, Wang, Yanming, Jacobs, Steven A., Kim, Youngchang, Allis, C. David, Khorasanizadeh, Sepideh
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory Press 2003
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Research Papers
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC196235/
https://ncbi.nlm.nih.gov/pubmed/12897054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1110503
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