Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains

On the histone H3 tail, Lys 9 and Lys 27 are both methylation sites associated with epigenetic repression, and reside within a highly related sequence motif ARKS. Here we show that the chromodomain proteins Polycomb (Pc) and HP1 (heterochromatin protein 1) are highly discriminatory for binding to th...

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Detalles Bibliográficos

Publicado en:	Genes Dev
Principais autores:	Fischle, Wolfgang, Wang, Yanming, Jacobs, Steven A., Kim, Youngchang, Allis, C. David, Khorasanizadeh, Sepideh
Formato:	Artigo
Idioma:	Inglês
Publicado:	Cold Spring Harbor Laboratory Press 2003
Assuntos:	Research Papers
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC196235/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12897054/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1110503
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