Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains

On the histone H3 tail, Lys 9 and Lys 27 are both methylation sites associated with epigenetic repression, and reside within a highly related sequence motif ARKS. Here we show that the chromodomain proteins Polycomb (Pc) and HP1 (heterochromatin protein 1) are highly discriminatory for binding to th...

Fuld beskrivelse

Bibliografiske detaljer

Udgivet i:	Genes Dev
Principais autores:	Fischle, Wolfgang, Wang, Yanming, Jacobs, Steven A., Kim, Youngchang, Allis, C. David, Khorasanizadeh, Sepideh
Format:	Artigo
Sprog:	Inglês
Udgivet:	Cold Spring Harbor Laboratory Press 2003
Fag:	Research Papers
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC196235/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12897054/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1110503
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!