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Characterization of a broad-range disulfide reductase from Streptomyces clavuligerus and its possible role in beta-lactam antibiotic biosynthesis.

Streptomyces clavuligerus is a potent producer of penicillin and cephalosporin antibiotics. A key step in the biosynthesis of these beta-lactam compounds is the cyclization of the thiol tripeptide delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine (ACV) to isopenicillin N by the enzyme isopenicillin N...

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Sonraí Bibleagrafaíochta
Main Authors: Aharonowitz, Y, Av-Gay, Y, Schreiber, R, Cohen, G
Formáid: Artigo
Teanga:Inglês
Foilsithe: 1993
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC196197/
https://ncbi.nlm.nih.gov/pubmed/8423136
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