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Regulated CPEB phosphorylation during meiotic progression suggests a mechanism for temporal control of maternal mRNA translation

CPEB is an mRNA-binding protein that stimulates polyadenylation-induced translation of maternal mRNA once it is phosphorylated on Ser 174 or Thr 171 (species-dependent). Disruption of the CPEB gene in mice causes an arrest of oogenesis at embryonic day 16.5 (E16.5), when most oocytes are in pachyten...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Tay, Joyce, Hodgman, Rebecca, Sarkissian, Madathia, Richter, Joel D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2003
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC196075/
https://ncbi.nlm.nih.gov/pubmed/12815066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1071403
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