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TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres
Mammalian telomeres are coated by the sequence-specific, DNA-binding protein, TRF1, a negative regulator of telomere length. Previous results showed that ADP-ribosylation of TRF1 by tankyrase 1 released TRF1 from telomeres and promoted telomere elongation. We now show that loss of TRF1 from telomere...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2003
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC196064/ https://ncbi.nlm.nih.gov/pubmed/12782650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1077103 |
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