Mice lacking a transcriptional corepressor Tob are predisposed to cancer

tob is a member of antiproliferative family genes. Mice lacking tob are prone to spontaneous formation of tumors. The occurrence rate of diethylnitrosamine-induced liver tumors is higher in tob(−/−) mice than in wild-type mice. tob(−/−)p53(−/−) mice show accelerated tumor formation in comparison wit...

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Detalhes bibliográficos
Main Authors: Yoshida, Yutaka, Nakamura, Takahisa, Komoda, Masato, Satoh, Hitoshi, Suzuki, Toru, Tsuzuku, Junko K., Miyasaka, Takashi, Yoshida, Eri H., Umemori, Hisashi, Kunisaki, Reiko K., Tani, Kenzaburo, Ishii, Shunsuke, Mori, Shigeo, Suganuma, Masami, Noda, Tetsuo, Yamamoto, Tadashi
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2003
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC196063/
https://ncbi.nlm.nih.gov/pubmed/12756225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1088003
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