Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction

Hedgehog (Hh) signaling is critical for many developmental events and must be restrained to prevent cancer. A transmembrane protein, Smoothened (Smo), is necessary to transcriptionally activate Hh target genes. Smo activity is blocked by the Hh transmembrane receptor Patched (Ptc). The reception of...

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Detalhes bibliográficos

Publicado no:	Genes Dev
Principais autores:	Zhu, Alan Jian, Zheng, Limin, Suyama, Kaye, Scott, Matthew P.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Cold Spring Harbor Laboratory Press 2003
Assuntos:	Research Paper
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC196058/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12730121/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1080803
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