RNA polymerase mutations that impair conversion to a termination-resistant complex by Q antiterminator proteins

Bacteriophage λ Q-protein stably binds and modifies RNA polymerase (RNAP) to a termination-resistant form. We describe amino acid substitutions in RNAP that disrupt Q-mediated antitermination in vivo and in vitro. The positions of these substitutions in the modeled RNAP/DNA/RNA ternary elongation co...

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Veröffentlicht in:	Genes Dev
Hauptverfasser:	Santangelo, Thomas J., Mooney, Rachel Anne, Landick, Robert, Roberts, Jeffrey W.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Cold Spring Harbor Laboratory Press 2003
Schlagworte:	Research Paper
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC196057/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12756229/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1082103
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