RNA polymerase mutations that impair conversion to a termination-resistant complex by Q antiterminator proteins

Bacteriophage λ Q-protein stably binds and modifies RNA polymerase (RNAP) to a termination-resistant form. We describe amino acid substitutions in RNAP that disrupt Q-mediated antitermination in vivo and in vitro. The positions of these substitutions in the modeled RNAP/DNA/RNA ternary elongation co...

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Detalhes bibliográficos
Main Authors: Santangelo, Thomas J., Mooney, Rachel Anne, Landick, Robert, Roberts, Jeffrey W.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2003
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC196057/
https://ncbi.nlm.nih.gov/pubmed/12756229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1082103
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