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NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions
Mutation of the Neurofibromatosis 2 (NF2) tumor suppressor gene leads to cancer development in humans and mice. Recent studies suggest that Nf2 loss also contributes to tumor metastasis. The Nf2-encoded protein, merlin, is related to the ERM (ezrin, radixin, and moesin) family of membrane:cytoskelet...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2003
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC196046/ https://ncbi.nlm.nih.gov/pubmed/12695331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1054603 |
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