CIAP1 and the serine protease HTRA2 are involved in a novel p53-dependent apoptosis pathway in mammals

Recently a Drosophila p53 protein has been identified that mediates apoptosis via a novel pathway involving the activation of the Reaper gene and subsequent inhibition of the inhibitors of apoptosis (IAPs). The present study found that CIAP1, a major mammalian homolog of Drosophila IAPs, is irrevers...

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Bibliographic Details

Published in:	Genes Dev
Main Authors:	Jin, Shengkan, Kalkum, Markus, Overholtzer, Michael, Stoffel, Archontoula, Chait, Brian T., Levine, Arnold J.
Format:	Artigo
Language:	Inglês
Published:	Cold Spring Harbor Laboratory Press 2003
Subjects:	Research Paper
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC195984/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12569127/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1047003
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