Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity

Expression of eukaryotic translation initiation factor 4E (eIF4E) is commonly elevated in human and experimental cancers, promoting angiogenesis and tumor growth. Elevated eIF4E levels selectively increase translation of growth factors important in malignancy (e.g., VEGF, cyclin D1) and is thereby a...

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Bibliographic Details
Main Authors: Graff, Jeremy R., Konicek, Bruce W., Vincent, Thomas M., Lynch, Rebecca L., Monteith, David, Weir, Spring N., Schwier, Phil, Capen, Andrew, Goode, Robin L., Dowless, Michele S., Chen, Yuefeng, Zhang, Hong, Sissons, Sean, Cox, Karen, McNulty, Ann M., Parsons, Stephen H., Wang, Tao, Sams, Lillian, Geeganage, Sandaruwan, Douglass, Larry E., Neubauer, Blake Lee, Dean, Nicholas M., Blanchard, Kerry, Shou, Jianyong, Stancato, Louis F., Carter, Julia H., Marcusson, Eric G.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2007
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1957541/
https://ncbi.nlm.nih.gov/pubmed/17786246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32044
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