Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16(INK4a) but not by the alternative reading frame protein p19(ARF)
The INK4a gene, one of the most frequently disrupted tumor suppressor loci in human cancer, encodes two unrelated proteins, p16(INK4a) and p19(ARF), each of which is capable of inducing cell cycle arrest. Splicing of alternative first exons (1α vs. 1β) to a common second exon within INK4a generates...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19571/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9012842/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.2.669 |
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