Epidermal growth factor receptor activation induces nuclear targeting of cyclooxygenase-2, basolateral release of prostaglandins, and mitogenesis in polarizing colon cancer cells

Nonsteroidal antiinflammatory drugs reduce the risk of colon cancer, possibly via cyclooxygenase (COX) inhibition. The growth factor-inducible COX-2, which is overexpressed in neoplastic colonic tissue, is an attractive target to mediate this effect. Herein we have exploited the ability of a human c...

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Bibliografiske detaljer
Main Authors: Coffey, Robert J., Hawkey, Chris J., Damstrup, Lars, Graves-Deal, Ramona, Daniel, Vincent C., Dempsey, Peter J., Chinery, Rebecca, Kirkland, Susan C., DuBois, Raymond N., Jetton, Thomas L., Morrow, Jason D.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences of the USA 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC19569/
https://ncbi.nlm.nih.gov/pubmed/9012840
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