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Epidermal growth factor receptor activation induces nuclear targeting of cyclooxygenase-2, basolateral release of prostaglandins, and mitogenesis in polarizing colon cancer cells

Nonsteroidal antiinflammatory drugs reduce the risk of colon cancer, possibly via cyclooxygenase (COX) inhibition. The growth factor-inducible COX-2, which is overexpressed in neoplastic colonic tissue, is an attractive target to mediate this effect. Herein we have exploited the ability of a human c...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Coffey, Robert J., Hawkey, Chris J., Damstrup, Lars, Graves-Deal, Ramona, Daniel, Vincent C., Dempsey, Peter J., Chinery, Rebecca, Kirkland, Susan C., DuBois, Raymond N., Jetton, Thomas L., Morrow, Jason D.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1997
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19569/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9012840/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.2.657
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