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Double-Stranded RNA-Dependent Protein Kinase Is Involved in 2-Methoxyestradiol–Mediated Cell Death of Osteosarcoma Cells

We studied the involvement of interferon-regulated, PKR on 2-ME–mediated actions in human osteosarcoma cells. Our results show that PKR is activated by 2-ME treatment and is necessary for 2-ME–mediated induction of osteosarcoma cell death. INTRODUCTION: Osteosarcoma is the most common primary bone t...

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Hlavní autoři: Shogren, Kristen L, Turner, Russell T, Yaszemski, Michael J, Maran, Avudaiappan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1955766/
https://ncbi.nlm.nih.gov/pubmed/17014383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1359/JBMR.060914
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