Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models

The nervous system-specific leucine-rich repeat Ig-containing protein LINGO-1 is associated with the Nogo-66 receptor complex and is endowed with a canonical EGF receptor (EGFR)-like tyrosine phosphorylation site. Our studies indicate that LINGO-1 expression is elevated in the substantia nigra of Pa...

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Dades bibliogràfiques
Autors principals: Inoue, Haruhisa, Lin, Ling, Lee, Xinhua, Shao, Zhaohui, Mendes, Shannon, Snodgrass-Belt, Pamela, Sweigard, Harry, Engber, Tom, Pepinsky, Blake, Yang, Lichuan, Beal, M. Flint, Mi, Sha, Isacson, Ole
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2007
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1955463/
https://ncbi.nlm.nih.gov/pubmed/17726113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700901104
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