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Reduction of arthritis following intra‐articular administration of an adeno‐associated virus serotype 5 expressing a disease‐inducible TNF‐blocking agent

BACKGROUND: In the context of preclinical development, we studied the potential of intra‐articular gene delivery using a recombinant adeno‐associated virus 5 (rAAV5) encoding a chimeric human tumour necrosis factorα (TNFα) soluble receptor I linked to a mouse immunoglobulin heavy chain Fc portion (T...

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Detalhes bibliográficos
Main Authors: Adriaansen, J, Khoury, M, de Cortie, C J, Fallaux, F J, Bigey, P, Scherman, D, Gould, D J, Chernajovsky, Y, Apparailly, F, Jorgensen, C, Vervoordeldonk, M J B M, Tak, P P
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1955149/
https://ncbi.nlm.nih.gov/pubmed/17363402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2006.064519
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