Activation of the epidermal growth factor signalling pathway by tissue plasminogen activator in pancreas cancer cells

BACKGROUND: Tissue plasminogen activator (tPA) is the major activator of plasminogen in plasma. This serine protease is overexpressed by exocrine pancreas tumour cells, where it promotes tumour cell proliferation, growth, and invasion. Here we have explored the signalling pathways used by tPA to act...

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Detalhes bibliográficos
Main Authors: Hurtado, Mariano, Lozano, Juan José, Castellanos, Elisabeth, López‐Fernández, Luis A, Harshman, Keith, Martínez‐A, Carlos, Ortiz, Angel R, Thomson, Timothy M, Paciucci, Rosanna
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2007
Assuntos:
Pancreatic Cancer
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1954978/
https://ncbi.nlm.nih.gov/pubmed/17452424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2006.097188
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