Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress
A significant amount of reactive oxygen species (ROS) is generated during mitochondrial oxidative phosphorylation. Several studies have suggested that mtDNA may accumulate more oxidative DNA damage relative to nuclear DNA. This study used quantitative PCR to examine the formation and repair of hydro...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19544/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9012815/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.2.514 |
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