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Tests of the Extension and Deadbolt Models of Integrin Activation

Despite extensive evidence that integrin conformational changes between bent and extended conformations regulate affinity for ligands, an alternative hypothesis has been proposed in which a “deadbolt” can regulate affinity for ligand in the absence of extension. Here, we tested both the deadbolt and...

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Detalles Bibliográficos
Autores principales: Zhu, Jieqing, Boylan, Brian, Luo, Bing-Hao, Newman, Peter J., Springer, Timothy A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1952534/
https://ncbi.nlm.nih.gov/pubmed/17301049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M700249200
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