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PAB1 Self-Association Precludes Its Binding to Poly(A), Thereby Accelerating CCR4 Deadenylation In Vivo

The mRNA deadenylation process, catalyzed by the CCR4 deadenylase, is known to be the major factor controlling mRNA decay rates in Saccharomyces cerevisiae. We have identified the proline-rich region and RRM1 domains of poly(A) binding protein (PAB1) as necessary for CCR4 deadenylation. Deletion of...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Yao, Gang, Chiang, Yueh-Chin, Zhang, Chongxu, Lee, Darren J., Laue, Thomas M., Denis, Clyde L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2007
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1952152/
https://ncbi.nlm.nih.gov/pubmed/17620415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00734-07
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