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PAB1 Self-Association Precludes Its Binding to Poly(A), Thereby Accelerating CCR4 Deadenylation In Vivo

The mRNA deadenylation process, catalyzed by the CCR4 deadenylase, is known to be the major factor controlling mRNA decay rates in Saccharomyces cerevisiae. We have identified the proline-rich region and RRM1 domains of poly(A) binding protein (PAB1) as necessary for CCR4 deadenylation. Deletion of...

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Main Authors: Yao, Gang, Chiang, Yueh-Chin, Zhang, Chongxu, Lee, Darren J., Laue, Thomas M., Denis, Clyde L.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2007
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גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1952152/
https://ncbi.nlm.nih.gov/pubmed/17620415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00734-07
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