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Regulation of Urokinase Receptor Expression by p53: Novel Role in Stabilization of uPAR mRNA
We found that p53-deficient (p53(−/−)) lung carcinoma (H1299) cells express robust levels of cell surface uPAR and uPAR mRNA. Expression of p53 protein in p53(−/−) cells suppressed basal and urokinase (uPA)-induced cell surface uPAR protein and increased uPAR mRNA degradation. Inhibition of p53 by R...
Sparad:
| Huvudupphovsmän: | , , , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society for Microbiology
2007
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1952137/ https://ncbi.nlm.nih.gov/pubmed/17548471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00080-07 |
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