Cytolysin-Dependent Escape of the Bacterium from the Phagosome Is Required but Not Sufficient for Induction of the Th1 Immune Response against Listeria monocytogenes Infection: Distinct Role of Listeriolysin O Determined by Cytolysin Gene Replacement

Listeria monocytogenes evades the antimicrobial mechanisms of macrophages by escaping from the phagosome into the cytosolic space via a unique cytolysin that targets the phagosomal membrane, listeriolysin O (LLO), encoded by hly. Gamma interferon (IFN-γ), which is known to play a pivotal role in the...

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Main Authors: Hara, Hideki, Kawamura, Ikuo, Nomura, Takamasa, Tominaga, Takanari, Tsuchiya, Kohsuke, Mitsuyama, Masao
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2007
Assuntos:
Molecular Pathogenesis
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1951982/
https://ncbi.nlm.nih.gov/pubmed/17517863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01779-06
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