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Functional Characterization by Genetic Complementation of aroB-Encoded Dehydroquinate Synthase from Mycobacterium tuberculosis H37Rv and Its Heterologous Expression and Purification

The recent recrudescence of Mycobacterium tuberculosis infection and the emergence of multidrug-resistant strains have created an urgent need for new therapeutics against tuberculosis. The enzymes of the shikimate pathway are attractive drug targets because this route is absent in mammals and, in M....

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Bibliografiske detaljer
Main Authors: de Mendonça, Jordana Dutra, Ely, Fernanda, Palma, Mario Sergio, Frazzon, Jeverson, Basso, Luiz Augusto, Santos, Diógenes Santiago
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1951933/
https://ncbi.nlm.nih.gov/pubmed/17586643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00425-07
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