LEKTI Fragments Specifically Inhibit KLK5, KLK7, and KLK14 and Control Desquamation through a pH-dependent Interaction

LEKTI is a 15-domain serine proteinase inhibitor whose defective expression underlies the severe autosomal recessive ichthyosiform skin disease, Netherton syndrome. Here, we show that LEKTI is produced as a precursor rapidly cleaved by furin, generating a variety of single or multidomain LEKTI fragm...

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Detalhes bibliográficos
Main Authors: Deraison, Celine, Bonnart, Chrystelle, Lopez, Frederic, Besson, Celine, Robinson, Ross, Jayakumar, Arumugam, Wagberg, Fredrik, Brattsand, Maria, Hachem, Jean Pierre, Leonardsson, Goran, Hovnanian, Alain
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1951746/
https://ncbi.nlm.nih.gov/pubmed/17596512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-02-0124
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