Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing

The human epidermis serves 2 crucial barrier functions: it protects against water loss and prevents penetration of infectious agents and allergens. The physiology of the epidermis is maintained by a balance of protease and antiprotease activities, as illustrated by the rare genetic skin disease Neth...

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Autori principali: Bonnart, Chrystelle, Deraison, Céline, Lacroix, Matthieu, Uchida, Yoshikazu, Besson, Céline, Robin, Aurélie, Briot, Anaïs, Gonthier, Marie, Lamant, Laurence, Dubus, Pierre, Monsarrat, Bernard, Hovnanian, Alain
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827963/
https://ncbi.nlm.nih.gov/pubmed/20179351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41440
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