A Rapid Progressor-Specific Variant Clone of Simian Immunodeficiency Virus Replicates Efficiently In Vivo Only in the Absence of Immune Reponses

A subset of simian immunodeficiency virus (SIV)-infected macaques progresses rapidly to disease with transient SIV-specific immune responses and high viral loads. Unique SIV variants with convergent Env mutations evolve in these rapid progressor (RP) macaques. To address the pathogenic significance...

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Detalhes bibliográficos
Main Authors: Kuwata, Takeo, Byrum, Russell, Whitted, Sonya, Goeken, Robert, Buckler-White, Alicia, Plishka, Ronald, Iyengar, Ranjini, Hirsch, Vanessa M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1951398/
https://ncbi.nlm.nih.gov/pubmed/17596304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00614-07
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