Comparisons of Mutants Lacking the Golgi UDP-Galactose or GDP-Mannose Transporters Establish that Phosphoglycans Are Important for Promastigote but Not Amastigote Virulence in Leishmania major

Abundant surface Leishmania phosphoglycans (PGs) containing [Gal(β1,4)Man(α1-PO(4))]-derived repeating units are important at several points in the infectious cycle of this protozoan parasite. PG synthesis requires transport of activated nucleotide-sugar precursors from the cytoplasm to the Golgi ap...

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Bibliographische Detailangaben
Hauptverfasser: Capul, Althea A., Hickerson, Suzanne, Barron, Tamara, Turco, Salvatore J., Beverley, Stephen M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2007
Schlagworte:
Fungal and Parasitic Infections
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1951182/
https://ncbi.nlm.nih.gov/pubmed/17606605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00735-07
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