A Discrete Class of Intergenic DNA Dictates Meiotic DNA Break Hotspots in Fission Yeast

Meiotic recombination is initiated by DNA double-strand breaks (DSBs) made by Spo11 (Rec12 in fission yeast), which becomes covalently linked to the DSB ends. Like recombination events, DSBs occur at hotspots in the genome, but the genetic factors responsible for most hotspots have remained elusive....

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Bibliographic Details
Main Authors: Cromie, Gareth A, Hyppa, Randy W, Cam, Hugh P, Farah, Joseph A, Grewal, Shiv I. S, Smith, Gerald R
Format: Artigo
Language:Inglês
Published: Public Library of Science 2007
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950956/
https://ncbi.nlm.nih.gov/pubmed/17722984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.0030141
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