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Development and Characterization of Recombinant Human Fc:OX40L fusion protein linked via a coiled-coil trimerization domain
OX40 (CD134) is a potent costimulatory molecule found on the surface of activated CD4(+) and CD8(+) T cells. Immunotherapy with OX40 agonists administered in vivo has demonstrated efficacy in several murine tumor models. A phase I clinical trial is currently underway in patients with advanced cancer...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1950941/ https://ncbi.nlm.nih.gov/pubmed/17374396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2007.02.004 |
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