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Genomewide Weighted Hypothesis Testing in Family-Based Association Studies, with an Application to a 100K Scan

For genomewide association (GWA) studies in family-based designs, we propose a novel two-stage strategy that weighs the association P values with the use of independently estimated weights. The association information contained in the family sample is partitioned into two orthogonal components—namel...

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Detalhes bibliográficos
Principais autores: Ionita-Laza, Iuliana , McQueen, Matthew B. , Laird, Nan M. , Lange, Christoph 
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Human Genetics 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950836/
https://ncbi.nlm.nih.gov/pubmed/17701906
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