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Influence of C-5 halogenation of uridines on hairpin versus duplex RNA folding
Halogenation of bases is a widespread method used for solving crystal structures of nucleic acids. However, this modification may have important consequences on RNA folding and thus on the success of crystallization. We have used a combination of UV thermal melting, steady-state fluorescence, X-ray...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1950758/ https://ncbi.nlm.nih.gov/pubmed/17630326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.408507 |
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