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The Intrinsic Antiretroviral Factor APOBEC3B Contains Two Enzymatically Active Cytidine Deaminase Domains

The mammalian APOBEC3 proteins are cytidine deaminases that function as inhibitors of retrovirus replication and retrotransposon mobility. An issue that has remained controversial is whether the editing of deoxycytidine residues to deoxyuridine is necessary and sufficient for this inhibition or whet...

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Detalhes bibliográficos
Main Authors: Bogerd, Hal P., Wiegand, Heather L., Doehle, Brian P., Cullen, Bryan R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950718/
https://ncbi.nlm.nih.gov/pubmed/17434555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2007.03.019
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