MOLECULAR MECHANISM OF HUMAN NRF2 ACTIVATION AND DEGRADATION: ROLE OF SEQUENTIAL PHOSPHORYLATION BY PROTEIN KINASE CK2

Nrf2 is a key transcription factor in the cellular response to oxidative stress. In this study we first identify two phosphorylated forms of endogenous human Nrf2 after chemically-induced oxidative stress and provide evidence that protein kinase CK2-mediated sequential phosphorylation plays potentia...

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Main Authors: Pi, Jingbo, Bai, Yushi, Reece, Jeffrey M., Williams, Jason, Liu, Dianxin, Freeman, Michael L., Fahl, William E., Shugar, David, Liu, Jie, Qu, Wei, Collins, Sheila, Waalkes, Michael P.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950666/
https://ncbi.nlm.nih.gov/pubmed/17512459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2007.03.001
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