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An RNAi-based Approach Identifies New Molecules Required for Glutamatergic and GABAergic Synapse Development

We report the results of a genetic screen to identify molecules important for synapse formation and/or maintenance. siRNAs were used to decrease the expression of candidate genes in neurons, and synapse development was assessed. We surveyed 22 cadherin family members and demonstrated distinct roles...

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Detalhes bibliográficos
Main Authors: Paradis, Suzanne, Harrar, Dana B., Lin, Yingxi, Koon, Alex C., Hauser, Jessica L., Griffith, Eric C., Zhu, Li, Brass, Lawrence F., Chen, Chinfei, Greenberg, Michael E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950560/
https://ncbi.nlm.nih.gov/pubmed/17224404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2006.12.012
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