Improved tumor imaging and therapy via i.v. IgG–mediated time-sequential modulation of neonatal Fc receptor

The long plasma half-life of IgG, while allowing for enhanced tumor uptake of tumor-targeted IgG conjugates, also results in increased background activity and normal-tissue toxicity. Therefore, successful therapeutic uses of conjugated antibodies have been limited to the highly sensitive and readily...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Singh Jaggi, Jaspreet, Carrasquillo, Jorge A., Seshan, Surya V., Zanzonico, Pat, Henke, Erik, Nagel, Andrew, Schwartz, Jazmin, Beattie, Brad, Kappel, Barry J., Chattopadhyay, Debjit, Xiao, Jing, Sgouros, George, Larson, Steven M., Scheinberg, David A.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Clinical Investigation 2007
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950462/
https://ncbi.nlm.nih.gov/pubmed/17717602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32226
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