B cell activator PAX5 promotes lymphomagenesis through stimulation of B cell receptor signaling

The presumed involvement of paired box gene 5 (PAX5) in B-lymphomagenesis is based largely on the discovery of Pax5-specific translocations and somatic hypermutations in non-Hodgkin lymphomas. Yet mechanistically, the contribution of Pax5 to neoplastic growth remains undeciphered. Here we used 2 Myc...

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Autors principals: Cozma, Diana, Yu, Duonan, Hodawadekar, Suchita, Azvolinsky, Anna, Grande, Shannon, Tobias, John W., Metzgar, Michele H., Paterson, Jennifer, Erikson, Jan, Marafioti, Teresa, Monroe, John G., Atchison, Michael L., Thomas-Tikhonenko, Andrei
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2007
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950455/
https://ncbi.nlm.nih.gov/pubmed/17717600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30842
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