Species-crossreactive scFv against the tumor stroma marker "fibroblast activation protein" selected by phage display from an immunized FAP-/- knock-out mouse.

BACKGROUND: Fibroblast activation protein (FAP) is a type II membrane protein expressed on tumor stroma fibroblasts in more than 90% of all carcinomas. FAP serves as a diagnostic marker and is potential therapeutic target for treatment of a wide variety of FAP+ carcinomas. Murine tumor stroma models...

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Autores principales: Brocks, B., Garin-Chesa, P., Behrle, E., Park, J. E., Rettig, W. J., Pfizenmaier, K., Moosmayer, D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2001
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950057/
https://ncbi.nlm.nih.gov/pubmed/11683371
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