Phosphatidylinositol-4,5 Bisphosphate Produced by PIP5KIγ Regulates Gelsolin, Actin Assembly, and Adhesion Strength of N-Cadherin Junctions

Phosphoinositides regulate several actin-binding proteins but their role at intercellular adhesions has not been defined. We found that phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) was generated at sites of N-cadherin–mediated intercellular adhesion and was a critical regulator of intercellul...

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Hlavní autoři: El Sayegh, T. Y., Arora, P. D., Ling, K., Laschinger, C., Janmey, P. A., Anderson, R. A., McCulloch, C. A.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Cell Biology 2007
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1949369/
https://ncbi.nlm.nih.gov/pubmed/17538019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-12-1159
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