Regulation of RasGRP1 by B Cell Antigen Receptor Requires Cooperativity between Three Domains Controlling Translocation to the Plasma Membrane

RasGRP1 is a Ras-activating exchange factor that is positively regulated by translocation to membranes. RasGRP1 contains a diacylglycerol-binding C1 domain, and it has been assumed that this domain is entirely responsible for RasGRP1 translocation. We found that the C1 domain can contribute to plasm...

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Main Authors: Beaulieu, Nadine, Zahedi, Bari, Goulding, Rebecca E., Tazmini, Ghazaleh, Anthony, Kira V., Omeis, Stephanie L., de Jong, Danielle R., Kay, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1949348/
https://ncbi.nlm.nih.gov/pubmed/17567957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E06-10-0932
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