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Interphase Nucleo-Cytoplasmic Shuttling and Localization of SIRT2 during Mitosis
The human NAD+-dependent protein deacetylase SIRT2 resides predominantly in the cytoplasm where it functions as a tubulin deacetylase. Here we report that SIRT2 maintains a largely cytoplasmic localization during interphase by active nuclear export in a Crm1-dependent manner. We identified a functio...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1949146/ https://ncbi.nlm.nih.gov/pubmed/17726514 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000784 |
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