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Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli
To which extent can optimality principles describe the operation of metabolic networks? By explicitly considering experimental errors and in silico alternate optima in flux balance analysis, we systematically evaluate the capacity of 11 objective functions combined with eight adjustable constraints...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1949037/ https://ncbi.nlm.nih.gov/pubmed/17625511 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb4100162 |
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