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Large-scale (13)C-flux analysis reveals mechanistic principles of metabolic network robustness to null mutations in yeast

BACKGROUND: Quantification of intracellular metabolite fluxes by (13)C-tracer experiments is maturing into a routine higher-throughput analysis. The question now arises as to which mutants should be analyzed. Here we identify key experiments in a systems biology approach with a genome-scale model of...

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Detalhes bibliográficos
Main Authors: Blank, Lars M, Kuepfer, Lars, Sauer, Uwe
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1175969/
https://ncbi.nlm.nih.gov/pubmed/15960801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2005-6-6-r49
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