Mechanism of interaction of optimized Limulus-derived cyclic peptides with endotoxins: thermodynamic, biophysical and microbiological analysis

On the basis of formerly investigated peptides corresponding to the endotoxin-binding domain from LALF [Limulus anti-LPS (lipopolysaccharide) factor], a protein from Limulus polyphemus, we have designed and synthesized peptides of different lengths with the aim of obtaining potential therapeutic age...

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Main Authors: Andrä, Jörg, Howe, Jörg, Garidel, Patrick, Rössle, Manfred, Richter, Walter, Leiva-León, José, Moriyon, Ignacio, Bartels, Rainer, Gutsmann, Thomas, Brandenburg, Klaus
Format: Artigo
Sprog:Inglês
Udgivet: Portland Press Ltd. 2007
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1948972/
https://ncbi.nlm.nih.gov/pubmed/17501719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20070279
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