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Additive effect of multiple pharmacological chaperones on maturation of CFTR processing mutants
The most common cause of CF (cystic fibrosis) is the deletion of Phe(508) (ΔF508) in the CFTR [CF TM (transmembrane) conductance regulator] chloride channel. One major problem with ΔF508 CFTR is that the protein is defective in folding so that little mature protein is delivered to the cell surface....
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Portland Press Ltd.
2007
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1948964/ https://ncbi.nlm.nih.gov/pubmed/17535157 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20070478 |
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