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The chemical chaperone CFcor-325 repairs folding defects in the transmembrane domains of CFTR-processing mutants
Most patients with CF (cystic fibrosis) express a CFTR [CF TM (transmembrane) conductance regulator] processing mutant that is not trafficked to the cell surface because it is retained in the endoplasmic reticulum due to altered packing of the TM segments. CL4 (cytoplasmic loop 4) connecting TMs 10...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1462697/ https://ncbi.nlm.nih.gov/pubmed/16417523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060013 |
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