Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity

Protein and peptide assembly into amyloid has been implicated in functions that range from beneficial epigenetic controls to pathological etiologies. However, the exact structures of the assemblies that regulate biological activity remain poorly defined. We have previously used Zn(2+) to modulate th...

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Hlavní autoři: Dong, Jijun, Canfield, Jeffrey M., Mehta, Anil K., Shokes, Jacob E., Tian, Bo, Childers, W. Seth, Simmons, James A., Mao, Zixu, Scott, Robert A., Warncke, Kurt, Lynn, David G.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1948904/
https://ncbi.nlm.nih.gov/pubmed/17686982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702669104
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