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A charge-based interaction between histone H4 and Dot1 is required for H3K79 methylation and telomere silencing: identification of a new trans-histone pathway

Saccharomyces cerevisiae cells lacking Dot1 exhibit a complete loss of H3K79 methylation and defects in heterochromatin-mediated silencing. To further understand the mechanism of Dot1-mediated methylation, the substrate requirement of Dot1 was determined. This analysis found that Dot1 requires histo...

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Detalles Bibliográficos
Main Authors: Fingerman, Ian M., Li, Hui-Chun, Briggs, Scott D.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1948857/
https://ncbi.nlm.nih.gov/pubmed/17675446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1560607
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