In situ hybridization analysis of presenilin 1 mRNA in Alzheimer disease and in lesioned rat brain

Presenilin-1 (PS-1) gene mutations are responsible for the majority of the early onset familial forms of Alzheimer disease (AD). Neither PS-1’s anatomic distribution in brain nor expression in AD have been reported. Using in situ hybridization in the rat forebrain, we show that PS-1 mRNA expression...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Page, Keith, Hollister, Richard, Tanzi, Rudolph E., Hyman, Bradley T.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1996
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19487/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8943053/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.24.14020
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